Human Genetics

Prof. Dr. Dr. med. Davor Lessel

Link to Human Genetics at the University Hospital (externer Link, ?ffnet neues Fenster)

Application to the Human Genetics module

Registration by 31st of July: Frau Dr. Fabiola Biasella (Fabiola.Biasella@klinik.uni-regensburg.de)

Hinweis zur Anmeldung zum Humangenetik Modul:

Die hohe Nachfrage nach Pl?tzen im Mastermodul ?Humangenetik‘ macht folgendes Prozedere erforderlich:Bitte bewerben Sie sich formell jeweils bis 31. Juli eines jeden Jahres für das kommende Wintersemester (per E-Mail an Fabiola.Biasella@klinik.uni-regensburg.de, Betreffzeile: Wahlmodul Humangenetik). Bitte fügen Sie der Bewerbung einen kurzen Lebenslauf einschlie?lich eines Notenspiegels erbrachter Klausur-und Prüfungsleistungen bei. Eventuell werden wir Sie im Anschluss zu einem kurzen Vorstellungsgespr?ch einladen. Sie erhalten bis sp?testens Ende Juli verbindlich Bescheid, ob Sie in das Modul aufgenommen werden k?nnen. Wir bitten Sie, uns bis Ende August zu benachrichtigen, ob Sie den Platz annehmen m?chten oder nicht. Alle nicht belegten Pl?tze werden dann in einem Nachrückverfahren bis Mitte September vergeben.

Application to the Human Genetics module

Due to the high demand of students to the “Human Genetics” module, a selection process takes place. Please send your application per E-Mail to Fabiola.Biasella@klinik.uni-regensburg.de with the Subject heading: Wahlmodul Humangenetik until July 31 if you want to start the module in the upcoming winter semester. The application should include a short curriculum vitae and a grade transcript. If needed, you will be invited to a short interview. Acceptance to the module will be communicated at the latest at the end of July. We request that you let us know until the end of August if you will take the module or not. Should there be free places left, these will be allotted until mid-September.

TM Human Genetics

BIO-M-TM-HG

Detailed module description - pdf (externer Link, ?ffnet neues Fenster)

Prof. Dr. Dr. med. Davor Lessel

Module contents
Lecture: Advanced Human Genetics Comprehensive basic information on modern topics of human genetics with a strong focus on genetic variation in health and disease: ? Organization of the human genome, gene expression and gene regulation ? Mendelian diseases: Basics, identification of new genetic causes, functional characterization of novel variants ? Cancer genetics ? Genetics of complex diseases (e.g. functionality of genetic polymorphisms, genome wide association studies, pathway analysis), population genetics, epigenetic mechanisms, pharmacogenetics ? Medical genetics including basic principles of genetic counseling and diagnostics ? Ethical, legal, and social issues related to genetic testing ? Principles of gene therapy (including genome editing) and application of induced pluripotent stem cell technology . Applied Human Genetics including Course Work This course provides deeper understanding of the impact of molecular biology and genetics on modern medicine and the connection between basic research, medical knowledge and an improved patient management. The concepts will be accompanied by theoretical introductions followed by a guided experimental course. Topics include, but are not limited to: ? Principles and specifics of modern DNA diagnostics ? From raw data to interpretation of genetic variants ? Cell culture and heterologous gene expression ? Induced pluripotent stem cell technology ? CRISPR-Cas mediated genome editing ? mRNA expression analysis ? Applications of confocal laser scanning microscopy ? Use of disease models in human genetics research . Literature Seminar in Human Genetics In this weekly seminar current peer reviewed publications in the field of human genetics are presented and discussed in-depth. Students give a brief power point presentation, followed by an interactive discussion with fellow students and staff of the Institute of Human Genetics.
Module components
1. Lectures Advanced Human Genetics (formerly called “Humangenetik I”) Applied Human Genetics Lecture and Lab Course (formerly called “Humangenetik II”) Please note that the written exam for Advanced Human Genetics is in German language only! Course work for the Applied Human Genetics part has to be conducted in English. 2. Human Genetics Literature Seminar (EXA 56121)
Module examination
30 min oral examination (graded); in English by request. Information on the oral examination and enrolment procedures will be provided during the 6-week internship.

Practical Module Human Genetics

BIO-M-PM-HG

Detailed module description - pdf (externer Link, ?ffnet neues Fenster)

Prof. Dr. Dr. med. Davor Lessel (link to research group (externer Link, ?ffnet neues Fenster))

Module contents
Standard laboratory techniques in molecular biology and genetics; in-depth experimental applications including standard and advanced methodologies Knowledge of and familiarization with public databases and software relevant to molecular genetics Application of cell culture and animal model systems to address clinically relevant questions Presentation and discussion of own data generated experimentally Communication of scientific results (lectures, posters, protocols) Overview of research areas in human genetics and advanced knowledge of experimental approaches in the field of molecular medical research
Module components
Laboratory course (6 weeks) with seminar: Human Genetics
Module examination
Portfolio examination (graded)

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